MaxWell Clinic was one of six clinical sites that participated in the EVANTHEA Dementia Reversal Trial.
The EVANTHEA trial studied a personalized precision-medicine approach for adults experiencing mild cognitive impairment or early-stage dementia.
This was a randomized controlled clinical trial evaluating a personalized precision-medicine approach involving comprehensive testing and individualized medical, functional, and lifestyle interventions. The study focused on adults with mild cognitive impairment or early-stage dementia.
The trial has concluded and is no longer enrolling participants. Preliminary findings are available in a preprint that has not yet undergone peer review.
Participants in the trial experienced symptoms associated with early dementia or mild cognitive impairment, which may include:
- Recently more forgetful
- Difficulty finding words
- Needs a list for everything
- Lost while walking or driving
- Difficulty with arithmetic
- Familiar tasks are difficult
What Was the EVANTHEA Dementia Reversal Trial?
Alzheimer’s disease is the most common cause of dementia, while mild cognitive impairment may represent an earlier stage of cognitive decline. The EVANTHEA trial evaluated participants whose cognitive testing was consistent with mild cognitive impairment or early-stage dementia.
The completed trial enrolled 73 participants with mild cognitive impairment or early-stage dementia across six clinical sites in the United States, including MaxWell Clinic in the Nashville area.
Participants were randomized into either a nine-month personalized precision-medicine treatment group or a nine-month standard-care group. After completing the study period, participants in the standard-care group were offered up to six months of the precision-medicine approach.
EVANTHEA Clinical Trial at MaxWell Clinic in Nashville
The EVANTHEA trial was conducted at the following clinical sites:
- Nashville, TN (MaxWell Clinic)
- Folsom, CA
- San Rafael, CA
- Walnut Creek, CA
- Hollywood, FL
- Rocky River, OH
The EVANTHEA trial has concluded and is no longer accepting applications. Information about the completed study and its preliminary findings is available through the official EVANTHEA website, the ClinicalTrials.gov study record, and the non-peer-reviewed preprint.
Preliminary EVANTHEA Trial Results
The completed trial enrolled 73 participants. Fifty participants were assigned to the personalized precision-medicine group, while 23 received standard care.
In a non-peer-reviewed preprint, the study authors reported statistically significant improvements in several cognitive measures in the precision-medicine group compared with the standard-care group. These measures included overall neurocognitive functioning, memory, executive function, and processing speed. MoCA scores showed a trend toward improvement but did not reach statistical significance.
These findings should be considered preliminary because the manuscript has not yet undergone peer review. The intervention evaluated in the trial is not FDA-approved for the treatment, cure, or prevention of Alzheimer’s disease, mild cognitive impairment, or dementia.
The EVANTHEA trial evaluated a comprehensive approach that combined personalized medical care with interventions involving nutrition, exercise, sleep, stress, and other factors potentially associated with cognitive decline. Additional research and peer review will be important for understanding the findings and their clinical implications.
Visit the official EVANTHEA Dementia Reversal Trial website for current study information and access to the preliminary results. The study is also listed on ClinicalTrials.gov under identifier NCT05894954.
Although the EVANTHEA trial is no longer enrolling participants, MaxWell Clinic continues to provide cognitive health evaluations and educational resources for people concerned about memory loss or cognitive decline. These clinical services are separate from participation in the completed EVANTHEA trial.
Learn more about MaxWell Clinic’s approach to cognitive health, dementia care, and Habitat Optimized Plasma Exchange® (H.O.P.E.).
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